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Defining alcohol-related phenotypes in humans. The Collaborative Study on the Genetics of Alcoholism.

  • Author(s): Bierut, Laura Jean
  • Saccone, Nancy L
  • Rice, John P
  • Goate, Alison
  • Foroud, Tatiana
  • Edenberg, Howard
  • Almasy, Laura
  • Conneally, P Michael
  • Crowe, Raymond
  • Hesselbrock, Victor
  • Li, TK
  • Nurnberger, John
  • Porjesz, Bernice
  • Schuckit, Marc A
  • Tischfield, Jay
  • Begleiter, Henri
  • Reich, Theodore
  • et al.
Abstract

Alcoholism is a disease that runs in families and results at least in part from genetic risk factors. The Collaborative Study on the Genetics of Alcoholism (COGA) is a Federally funded effort to identify and characterize those genetic factors. The study involves more than 1,000 alcoholic subjects and their families, with researchers conducting comprehensive psychological, physiological, electrophysiological, and genetic analyses of the participants. These analyses have identified several traits, or phenotypes, that appear to be genetically determined, such as the presence of alcohol dependence, the level of response to alcohol, the presence of coexisting depression, or the maximum number of drinks a person consumes per occasion. Genetic analyses have identified regions on several chromosomes that are associated with these phenotypes and need to be studied further.

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