Skip to main content
eScholarship
Open Access Publications from the University of California

Elevation of cerebral proteases after systemic administration of aluminum

  • Author(s): Guo-Ross, S
  • Yang, E
  • Bondy, SC
  • et al.
Abstract

The levels of three proteases in the cerebral cortex of rats following a three week exposure to aluminum, were measured. The activity of apopain (CPP32), an interleukin 1β converting enzyme (ICE)-like cysteine protease specifically associated with apoptosis, was increased following dosing with aluminum. The activity of calcium-activated neutral protease, calpain, was also increased. However, the enzyme activity of trypsin-like serine protease, known to be elevated by oxidative events, was unchanged. Since aluminum is suspected as a possible factor in the pathogenesis of Alzheimer's disease and other neurological diseases, it is speculated that changed levels in proteolytic enzymes may relate to the neurotoxicity of aluminum.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View