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β-amyloid disrupts human NREM slow waves and related hippocampus-dependent memory consolidation
Published Web Location
https://doi.org/10.1038/nn.4035Abstract
The mechanisms through which β-amyloid impairs human memory remain unclear. This study shows that regional-specific β-amyloid load in cognitively normal older adults impairs NREM slow wave oscillations, thereby compromising overnight hippocampus-dependent memory consolidation. NREM sleep disruption therefore represents a novel mechanistic pathway through which β-amyloid contributes to hippocampus-dependent memory dysfunction in later life.
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