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Multifunctional and Scalable Nanoparticles for Bimodal Image-Guided Phototherapy in Bladder Cancer Treatment

Abstract

HighlightsPyropheophorbide a–bisaminoquinoline conjugate lipid nanoparticles (PPBC LNPs), formulated with lipid-based excipients and assembled using microfluidics, exhibit excellent biocompatibility and stability, indicating promise for clinical applications.PPBC LNPs possess remarkable photoacoustic and fluorescence imaging capabilities, enabling high-resolution, deep tissue penetration and high sensitivity imaging for tracking drug biodistribution and phototherapy efficacy.

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