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Physical mechanism for gating and mechanosensitivity of the human TRAAK K+ channel

Published Web Location

https://doi.org/10.1038/nature14013
Abstract

X-ray structures of the human TRAAK mechanosensitive potassium channel reveal how build-up of tension in the lipid membrane can convert the channel from a non-conducting wedge shape associated with an inserted lipid acyl chain that blocks the pore to an expanded cross-sectional shape that prevents lipid entry and thus permits ion conduction.

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