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Open Access Publications from the University of California

Heterotrimeric G protein-coupled receptor signaling in yeast mating pheromone response

  • Author(s): Alvaro, CG
  • Thorner, J
  • et al.

© 2016 by The American Society for Biochemistry and Molecular Biology, Inc. The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeast Saccharomyces cerevisiae were isolated in 1985, and were the very first genes for agonist-binding heterotrimericGprotein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview.

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