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Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response.

  • Author(s): Alvaro, Christopher G;
  • Thorner, Jeremy
  • et al.
Abstract

The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeastSaccharomyces cerevisiaewere isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview.

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