Heterotrimeric G Protein-coupled Receptor Signaling in Yeast Mating Pheromone Response.
- Author(s): Alvaro, Christopher G
- Thorner, Jeremy
- et al.
Published Web Locationhttps://doi.org/10.1074/jbc.r116.714980
The DNAs encoding the receptors that respond to the peptide mating pheromones of the budding yeastSaccharomyces cerevisiaewere isolated in 1985, and were the very first genes for agonist-binding heterotrimeric G protein-coupled receptors (GPCRs) to be cloned in any organism. Now, over 30 years later, this yeast and its receptors continue to provide a pathfinding experimental paradigm for investigating GPCR-initiated signaling and its regulation, as described in this retrospective overview.