Skip to main content
Open Access Publications from the University of California


UC San Francisco Electronic Theses and Dissertations bannerUCSF

Effects of Non-Surgical Periodontal Treatment on Chronic Kidney Disease Parameters: A Randomized clinical Trial

  • Author(s): Madi, Iman Moha
  • Advisor(s): Ryder, Mark
  • Young, Nathan
  • et al.

Chronic Kidney disease (CKD) is a broad spectrum of several conditions affecting 26 million American. Over 67 million adults 30 years or older are suffering from periodontal disease. Both conditions are influenced by many confounding conditions such as diabetes, smoking, stress and other inflammatory conditions. Current evidence shows a possible associated between CKD and periodontal disease. The purpose of this study was to see if treatment of periodontal disease in low socioeconomic patients with CKD and periodontal disease can have a positive effect on CKD parameters. 46 patients qualified for and completed this study. Patients were divided into an intervention and a control group and were examined at baseline, 4 months, 8 months and 12 months. Various kidney function parameters were also recorded through blood and urine samples at these appointments. The periodontal condition of the intervention group was treated with scaling and root planing, extractions and local delivery of minocycline polymers in probing pocket depths of 5mm or more and oral hygiene instruction. The control group was only given oral hygiene instruction handouts during these visits and extraction of their hopeless teeth. The control group received SRP and minocycline administration at the conclusion of the study. Both groups showed improvements in probing pocket depths, clinical attachment levels, bleeding on probing, plaque index and gingival index. These trends were stronger in the intervention group but not enough to be considered as healthy periodontium. Thus, the improvement in the periodontal state was not adequate enough to be assessed for influencing the kidney parameters. There was no difference between the two groups in kidney parameters.

Main Content
Current View