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Open Access Publications from the University of California

Serum TNF-α in psoriasis after treatment with propylthiouracil, an antithyroid thioureylene

  • Author(s): Elias, AN
  • Nanda, VS
  • Pandian, R
  • et al.

Background: Tumor necrosis factor-α (TNF-α) and its receptors play important roles in the development and persistence of psoriatic plaques. The antithyroid thioureylenes, propylthiouracil and methimazole, are effective in the treatment of patients with psoriasis with a significant number of patients showing clearing or near clearing of their lesions after a several weeks of treatment. Methods: The present study examined the effect of treatment with propylthiouracil, given in a dose of 100 mg every 8 hours for 3 months, on the serum levels of TNF-α in 9 patients with plaque psoriasis. Results: Propylthiouracil therapy did not result in a significant decline in serum TNF-α concentrations. Conclusions: The findings suggest that the therapeutic effect of propylthiouracil in psoriasis appears not to be related to any change in the concentration of TNF-α but occurs via an antiproliferative mechanism as we have previously speculated. © 2004 Elias et al; licensee BioMed Central Ltd.

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