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SnapShot: Talin and the Modular Nature of the Integrin Adhesome

Published Web Location

https://doi.org/10.1016/j.cell.2014.02.048
Abstract

Integrin αβ transmembrane heterodimers play central roles in metazoan development and physiology by mediating adhesion and by transmitting forces and biochemical signals across the plasma membrane. In this SnapShot, we present a simplified "modular" view of the integrin adhesome, centered on the talin-integrin interaction, and provide examples of how this view can help to unravel the adhesome's remarkable functional diversity and plasticity.

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