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Vitamin C induces Tet-dependent DNA demethylation and a blastocyst-like state in ES cells

  • Author(s): Ramalho-Santos, Miguel
  • Laird, Diana
  • Blaschke, K
  • Ebata, KT
  • Karimi, MM
  • Zepeda-Martínez, JA
  • Goyal, P
  • Mahapatra, S
  • Tam, A
  • Laird, DJ
  • Hirst, M
  • Rao, A
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3893718?pdf=render
No data is associated with this publication.
Abstract

DNA methylation is a heritable epigenetic modification involved in gene silencing, imprinting, and the suppression of retrotransposons. Global DNA demethylation occurs in the early embryo and the germ line, and may be mediated by Tet (ten eleven translocat

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