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Pilot study of an Alzheimer's disease risk assessment program in a primary care setting.

  • Author(s): Korthauer, Laura E
  • Denby, Charles
  • Molina, David
  • Wanjiku, Janet
  • Daiello, Lori A
  • Drake, Jonathan D
  • Grill, Josh D
  • Ott, Brian R
  • et al.
Abstract

Introduction

The goal of this study was to pilot a referral-based cognitive screening and genetic testing program for Alzheimer's disease (AD) risk assessment in a primary care setting.

Methods

Primary care providers (PCPs; N = 6) referred patients (N = 94; = 63 years) to the Rhode Island Alzheimer's Disease Prevention Registry for apolipoprotein E (APOE) genotyping and cognitive screening. PCPs disclosed test results to patients and counseled them about risk factor modification.

Results

Compared to the Registry as a whole, participants were younger, more likely to be non-White, and had lower cognitive screening scores. Mild cognitive impairment participants correctly reported a higher perceived risk of developing AD. Patients who recalled being counseled about modifiable risk factors were more likely to report positive health behavior changes.

Discussion

A referral-based program for cognitive and genetic AD risk assessment in a primary care setting is feasible, acceptable to patients, and yielded a more demographically diverse sample than an AD prevention registry.

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