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SIRT1 deacetylates RORγt and enhances Th17 cell generation
- Ott, Melanie;
- Akassoglou, Aikaterini;
- Verdin, Eric;
- Lim, HW;
- Kang, SG;
- Ryu, JK;
- Schilling, B;
- Fei, M;
- Lee, IS;
- Kehasse, A;
- Shirakawa, K;
- Yokoyama, M;
- Schnölzer, M
Published Web Location
http://europepmc.org/articles/PMC4419343?pdf=renderNo data is associated with this publication.
Abstract
© 2015 Lim et al.The balance of effector and regulatory T cell function, dependent on multiple signals and epigenetic regulators, is critical to immune self-tolerance. Dysregulation of T helper 17 (Th17) effector cells is associated with multiple autoimmun
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