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Control of the innate immune response by the mevalonate pathway
- Akula, Murali K;
- Shi, Man;
- Jiang, Zhaozhao;
- Foster, Celia E;
- Miao, David;
- Li, Annie S;
- Zhang, Xiaoman;
- Gavin, Ruth M;
- Forde, Sorcha D;
- Germain, Gail;
- Carpenter, Susan;
- Rosadini, Charles V;
- Gritsman, Kira;
- Chae, Jae Jin;
- Hampton, Randolph;
- Silverman, Neal;
- Gravallese, Ellen M;
- Kagan, Jonathan C;
- Fitzgerald, Katherine A;
- Kastner, Daniel L;
- Golenbock, Douglas T;
- Bergo, Martin O;
- Wang, Donghai
Published Web Location
https://doi.org/10.1038/ni.3487Abstract
Deficiency in mevalonate kinase causes autoinflammatory disease. Wang and colleagues define the detailed mechanistic basis that leads to this disease phenotype in mice and humans.
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