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Open Access Publications from the University of California

Aerobic Exercise for Alzheimer’s Disease

  • Author(s): Fan, Flora
  • Lee, Jungmin
  • Liu, Cynthia
  • Monder, Simran
  • Vedagarbha, Namrata
  • Xue, Mary
  • Binoy, Sharon
  • et al.

There is growing interest in the potential of exercise interventions in therapy forindividuals with Alzheimer’s disease (AD). This paper replicates and extends upon some of theanalysis of a randomized controlled pilot study that investigates the effect of a 26-week aerobicexercise program on memory, executive function, functional ability, and depression in 68participants who were likely to develop AD. The replication was focused specifically on theanalysis performed on the Memory Composite outcome variable, reproducing an interactionmodel between two of the main variables, Treatment Arm (Stretching and Toning Exerciseversus Aerobic Exercise) and Timepoint (Baseline, Week 13, Week 26). The replication yieldedthe same values as the original study with similarly insignificant p-values. Using RStudio, thepresent study tests three additional interaction models, the interaction between Sex andTreatment Arm, between Sex and Timepoint, and between Sex, Treatment Arm, and Timepoint.These tests yielded insignificant p-values, implying that, contrary to the previous literature ongender differences in AD and exercise interventions, gender may not be a differentiating factorin memory. The hypothesis was that the exercise type affects the interaction between time andmemory loss in early AD patients.

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