Volitional modulation of optically recorded calcium signals during neuroprosthetic learning.
- Author(s): Clancy, Kelly B
- Koralek, Aaron C
- Costa, Rui M
- Feldman, Daniel E
- Carmena, Jose M
- et al.
Published Web Locationhttps://doi.org/10.1038/nn.3712
Brain-machine interfaces are not only promising for neurological applications, but also powerful for investigating neuronal ensemble dynamics during learning. We trained mice to operantly control an auditory cursor using spike-related calcium signals recorded with two-photon imaging in motor and somatosensory cortex. Mice rapidly learned to modulate activity in layer 2/3 neurons, evident both across and within sessions. Learning was accompanied by modifications of firing correlations in spatially localized networks at fine scales.