Skip to main content
eScholarship
Open Access Publications from the University of California

Volitional modulation of optically recorded calcium signals during neuroprosthetic learning

  • Author(s): Clancy, KB
  • Koralek, AC
  • Costa, RM
  • Feldman, DE
  • Carmena, JM
  • et al.

Published Web Location

https://doi.org/10.1038/nn.3712
Abstract

Brain-machine interfaces are not only promising for neurological applications, but also powerful for investigating neuronal ensemble dynamics during learning. We trained mice to operantly control an auditory cursor using spike-related calcium signals recorded with two-photon imaging in motor and somatosensory cortex. Mice rapidly learned to modulate activity in layer 2/3 neurons, evident both across and within sessions. Learning was accompanied by modifications of firing correlations in spatially localized networks at fine scales. © 2014 Nature America, Inc.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View