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Open Access Publications from the University of California

Volitional modulation of optically recorded calcium signals during neuroprosthetic learning

  • Author(s): Clancy, KB
  • Koralek, AC
  • Costa, RM
  • Feldman, DE
  • Carmena, JM
  • et al.

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Brain-machine interfaces are not only promising for neurological applications, but also powerful for investigating neuronal ensemble dynamics during learning. We trained mice to operantly control an auditory cursor using spike-related calcium signals recorded with two-photon imaging in motor and somatosensory cortex. Mice rapidly learned to modulate activity in layer 2/3 neurons, evident both across and within sessions. Learning was accompanied by modifications of firing correlations in spatially localized networks at fine scales. © 2014 Nature America, Inc.

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