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Volitional modulation of optically recorded calcium signals during neuroprosthetic learning.

  • Author(s): Clancy, Kelly B
  • Koralek, Aaron C
  • Costa, Rui M
  • Feldman, Daniel E
  • Carmena, Jose M
  • et al.

Published Web Location

https://doi.org/10.1038/nn.3712
Abstract

Brain-machine interfaces are not only promising for neurological applications, but also powerful for investigating neuronal ensemble dynamics during learning. We trained mice to operantly control an auditory cursor using spike-related calcium signals recorded with two-photon imaging in motor and somatosensory cortex. Mice rapidly learned to modulate activity in layer 2/3 neurons, evident both across and within sessions. Learning was accompanied by modifications of firing correlations in spatially localized networks at fine scales.

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