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Open Access Publications from the University of California

Targeting Gli transcription activation by small molecule suppresses tumor growth

  • Author(s): Jablons, David
  • Bosco-Clément, G
  • Zhang, F
  • Chen, Z
  • Zhou, HM
  • Li, H
  • Mikami, I
  • Hirata, T
  • Yagui-Beltran, A
  • Lui, N
  • Do, HT
  • et al.

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Targeted inhibition of Hedgehog signaling at the cell membrane has been associated with anticancer activity in preclinical and early clinical studies. Hedgehog signaling involves activation of Gli transcription factors that can also be induced by alternati

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