Chronic wounds remain a serious burden in our health system, with limited therapeutic options available to improve healing. Approximately 2.5 million people experience chronic venous insufficiency (CVI) in the U.S. alone, of which 20% develop venous leg ulcers (VLU). Venous leg ulcers (VLU) are among the most common etiologies of chronic wounds, accounting for approximately 70% of ulcers.