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Brain morphometric differences in youth with and without perinatally-acquired HIV: A cross-sectional study.

  • Author(s): Lewis-de Los Angeles, C Paula
  • Williams, Paige L
  • Jenkins, Lisanne M
  • Huo, Yanling
  • Malee, Kathleen
  • Alpert, Kathryn I
  • Uban, Kristina A
  • Herting, Megan M
  • Csernansky, John G
  • Nichols, Sharon L
  • Van Dyke, Russell B
  • Sowell, Elizabeth R
  • Wang, Lei
  • Pediatric HIV/AIDS Cohort Study (PHACS) and the Pediatric Imaging, Neurocognition, and Genetics (PING) Study
  • et al.

Youth with perinatally-acquired HIV (PHIV) experience specific and global cognitive deficits at increased rates compared to typically-developing HIV-uninfected youth. In youth with PHIV, HIV infects the brain early in development. Neuroimaging studies have demonstrated altered grey matter morphometry in youth with PHIV compared to typically-developing youth. This study examined cortical thickness, surface area, and gyrification of grey matter in youth (age 11-20 years old) with PHIV (n = 40) from the Pediatric HIV/AIDS Cohort Study (PHACS) compared to typically-developing presumed HIV uninfected and unexposed youth (n = 80) from the Pediatric Imaging, Neurocognition and Genetics Study (PING) using structural magnetic resonance imaging. This study also examined the relationship between grey matter morphometry and age. Youth with PHIV had reduced cortical thickness, surface area, and gyrification compared to typically-developing youth. In addition, an inverse relationship between age and grey matter volume was found in typically-developing youth, but was not observed in youth with PHIV. Longitudinal studies are necessary to understand the neurodevelopmental trajectory of youth with PHIV.

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