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Activation of Hsp70 reduces neurotoxicity by promoting polyglutamine protein degradation
Published Web Location
http://europepmc.org/articles/PMC3552084?pdf=renderNo data is associated with this publication.
Abstract
We sought new strategies to reduce amounts of the polyglutamine androgen receptor (polyQ AR) and achieve benefits in models of spinobulbar muscular atrophy, a protein aggregation neurodegenerative disorder. Proteostasis of the polyQ AR is controlled by the
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