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Selective regulation of lymphopoiesis and leukemogenesis by individual zinc fingers of Ikaros
- Schjerven, Hilde;
- McLaughlin, Jami;
- Arenzana, Teresita L;
- Frietze, Seth;
- Cheng, Donghui;
- Wadsworth, Sarah E;
- Lawson, Gregory W;
- Bensinger, Steven J;
- Farnham, Peggy J;
- Witte, Owen N;
- Smale, Stephen T
Published Web Location
http://www.ncbi.nlm.nih.gov/pubmed/?term=schjervan+witteAbstract
The transcription factor Ikaros, which is essential for lymphocyte development, contains multiple zinc fingers. Smale and colleagues show that mice lacking different zinc fingers develop distinct lymphocyte-developmental defects and tumor susceptibility.
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