Skip to main content
eScholarship
Open Access Publications from the University of California
Refine Search

UC San Diego

UC San Diego Previously Published Works bannerUC San Diego

Masking thiol reactivity with thioamide, thiourea, and thiocarbamate-based MBPs.

Published Web Location

https://doi.org/10.1039/d2cc06596g
Abstract

Thioamides, thioureas, and thiocarbamates are introduced as stable, sulfur-based metal-binding pharmacophores (MBPs) for use in metalloenzyme fragment-based drug discovery (mFBDD). MBP reactivity, bioactivity, and structural studies show that these molecules can act as ligands for Zn(II)-dependent metalloenzymes including human carbonic anhydrase II (hCAII) and matrix metalloproteinase-2 (MMP-2).

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.


Top