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Structures of human ADAR2 bound to dsRNA reveal base-flipping mechanism and basis for site selectivity
- Matthews, Melissa M;
- Thomas, Justin M;
- Zheng, Yuxuan;
- Tran, Kiet;
- Phelps, Kelly J;
- Scott, Anna I;
- Havel, Jocelyn;
- Fisher, Andrew J;
- Beal, Peter A
Published Web Location
https://doi.org/10.1038/nsmb.3203Abstract
Crystal structures of the human ADAR2 deaminase domain in complex with RNA duplexes reveal the mechanisms for ADAR2's action and explain its substrate preference. The work also provides a rationale to understand disease-related mutations.
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