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Discovery and Biosynthesis of Clostyrylpyrones from the Obligate Anaerobe Clostridium roseum
- Li, Jeffrey S;
- Du, Yongle;
- Gu, Di;
- Cai, Wenlong;
- Green, Allison;
- Ng, Samuel;
- Leung, Alexander;
- Del Rio Flores, Antonio;
- Zhang, Wenjun
Published Web Location
https://doi.org/10.1021/acs.orglett.0c02656Abstract
Anaerobic bacteria are a promising new source for natural product discovery. Examination of extracts from the obligate anaerobe Clostridium roseum led to the discovery of a new family of natural products, the clostyrylpyrones. The polyketide synthase-based biosynthetic mechanism of clostyrylpyrones is further proposed on the basis of bioinformatic, gene knockout, biochemical analysis, and heterologous expression studies.
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