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Covalent docking of large libraries for the discovery of chemical probes

  • Author(s): Shoichet, Brian
  • Taunton, Jack
  • London, N
  • Miller, RM
  • Krishnan, S
  • Uchida, K
  • Irwin, JJ
  • Eidam, O
  • Gibold, L
  • Cimermančič, P
  • Bonnet, R
  • Shoichet, BK
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4232467?pdf=render
No data is associated with this publication.
Abstract

Chemical probes that form a covalent bond with a protein target often show enhanced selectivity, potency and utility for biological studies. Despite these advantages, protein-reactive compounds are usually avoided in high-throughput screening campaigns. He

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