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Histopathological features of papillary thyroid carcinomas detected during four screening examinations of a Ukrainian-American cohort.

  • Author(s): Bogdanova, Tetiana I
  • Zurnadzhy, Liudmyla Yu
  • Nikiforov, Yuri E
  • Leeman-Neill, Rebecca J
  • Tronko, Mykola D
  • Chanock, Stephen
  • Mabuchi, Kiyohiko
  • Likhtarov, Ilya A
  • Kovgan, Leonila M
  • Drozdovitch, Vladimir
  • Little, Mark P
  • Hatch, Maureen
  • Zablotska, Lydia B
  • Shpak, Viktor M
  • McConnell, Robert J
  • Brenner, Alina V
  • et al.

Published Web Location

https://www.nature.com/bjc/journal/v113/n11/full/bjc2015372a.html
No data is associated with this publication.
Abstract

There are limited data on the histopathology of papillary thyroid carcinomas (PTCs) diagnosed in irradiated populations. We evaluated the associations between iodine-131 dose and the histopathological characteristics of post-Chernobyl PTCs, the changes in these characteristics over time, and their associations with selected somatic mutations.This study included 115 PTCs diagnosed in a Ukrainian-American cohort (n=13,243) during prescreening and four successive thyroid screenings. Of these PTCs, 65 were subjected to somatic mutation profiling. All individuals were <18 years at the time of the Chernobyl accident and had direct thyroid radioactivity measurements. Statistical analyses included multivariate linear and logistic regression.We identified a borderline significant linear-quadratic association (P=0.063) between iodine-131 dose and overall tumour invasiveness (presence of extrathyroidal extension, lymphatic/vascular invasion, and regional or distant metastases). Irrespective of dose, tumours with chromosomal rearrangements were more likely to have lymphatic/vascular invasion than tumours without chromosomal rearrangements (P=0.020) or tumours with BRAF or RAS point mutations (P=0.008). Controlling for age, there were significant time trends in decreasing tumour size (P<0.001), the extent of lymphatic/vascular invasion (P=0.005), and overall invasiveness (P=0.026).We determined that the invasive properties of PTCs that develop in iodine-131-exposed children may be associated with radiation dose. In addition, based on a subset of cases, tumours with chromosomal rearrangements appear to have a more invasive phenotype. The increase in small, less invasive PTCs over time is a consequence of repeated screening examinations.

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