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Ten years of anti-vascular endothelial growth factor therapy

Published Web Location

https://doi.org/10.1038/nrd.2015.17
Abstract

Over the past 10 years, targeting vascular endothelial growth factor A (VEGFA) has been widely pursued in the treatment of various cancers and ophthalmic diseases. Here, Ferrara and Adamis provide an overview of the discovery of VEGFA and the development of anti-VEGFA therapies, addressing key challenges and issues that remain in the application of these agents.

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