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Colloidal drug formulations can explain "bell-shaped" concentration-response curves
- Shoichet, Brian;
- Owen, SC;
- Doak, AK;
- Ganesh, AN;
- Nedyalkova, L;
- McLaughlin, CK;
- Shoichet, BK;
- Shoichet, MS
Published Web Location
http://europepmc.org/articles/PMC3985758?pdf=renderNo data is associated with this publication.
Abstract
Drug efficacy does not always increase sigmoidally with concentration, which has puzzled the community for decades. Unlike standard sigmoidal curves, bell-shaped concentration-response curves suggest more complex biological effects, such as multiple-bindin
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