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Ectopic lymphoid structures function as microniches for tumor progenitor cells in hepatocellular carcinoma
- Finkin, Shlomi;
- Yuan, Detian;
- Stein, Ilan;
- Taniguchi, Koji;
- Weber, Achim;
- Unger, Kristian;
- Browning, Jeffrey L;
- Goossens, Nicolas;
- Nakagawa, Shigeki;
- Gunasekaran, Ganesh;
- Schwartz, Myron E;
- Kobayashi, Masahiro;
- Kumada, Hiromitsu;
- Berger, Michael;
- Pappo, Orit;
- Rajewsky, Klaus;
- Hoshida, Yujin;
- Karin, Michael;
- Heikenwalder, Mathias;
- Ben-Neriah, Yinon;
- Pikarsky, Eli
Published Web Location
https://doi.org/10.1038/ni.3290Abstract
Ectopic lymphoid structures develop at sites of chronic inflammation and are generally thought to be beneficial in the control of cancer. Pikarsky and colleagues show that these structures can instead nurture liver tumor progenitor cells.
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