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GLP-1 acts on habenular avoidance circuits to control nicotine intake
- Tuesta, Luis M;
- Chen, Zuxin;
- Duncan, Alexander;
- Fowler, Christie D;
- Ishikawa, Masago;
- Lee, Brian R;
- Liu, Xin-An;
- Lu, Qun;
- Cameron, Michael;
- Hayes, Matthew R;
- Kamenecka, Theodore M;
- Pletcher, Matthew;
- Kenny, Paul J
Published Web Location
https://doi.org/10.1038/nn.4540Abstract
Nicotine has rewarding effects that motivate its consumption. In addition to these rewarding effects, nicotine also has aversive properties that motivate its avoidance. Here the authors identify a pathway in the brain that regulates nicotine avoidance. Adaptive responses in this and other aversion-related pathways may contribute to the development of tobacco addiction.
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