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Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins

  • Author(s): Costello, Joseph
  • Maeder, ML
  • Angstman, JF
  • Richardson, ME
  • Linder, SJ
  • Cascio, VM
  • Tsai, SQ
  • Ho, QH
  • Sander, JD
  • Reyon, D
  • Bernstein, BE
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3858462?pdf=render
No data is associated with this publication.
Abstract

Genome-wide studies have defined cell type-specific patterns of DNA methylation that are important for regulating gene expression in both normal development and disease. However, determining the functional significance of specific methylation events remain

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