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Targeted DNA demethylation and activation of endogenous genes using programmable TALE-TET1 fusion proteins

Published Web Location

http://europepmc.org/articles/PMC3858462?pdf=render
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Abstract

Genome-wide studies have defined cell type-specific patterns of DNA methylation that are important for regulating gene expression in both normal development and disease. However, determining the functional significance of specific methylation events remain

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