Skip to main content
eScholarship
Open Access Publications from the University of California
Refine Search

UC Berkeley

UC Berkeley Previously Published Works bannerUC Berkeley

Conformational dynamics of a class C G-protein-coupled receptor

Published Web Location

https://doi.org/10.1038/nature14679
Abstract

smFRET is used to probe the activation mechanism of two full-length mammalian glutamate receptors, revealing that the extracellular ligand-binding domains of these G-protein-coupled receptors interconvert between three confirmations (resting, activated and a short-lived intermediate state), and that the efficacy of an orthosteric agonist correlates with the degree of occupancy of the active state.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.


Top