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Open Access Publications from the University of California

Reversible targeting of noncatalytic cysteines with chemically tuned electrophiles

  • Author(s): Taunton, Jack
  • Serafimova, IM
  • Pufall, MA
  • Krishnan, S
  • Duda, K
  • Cohen, MS
  • Maglathlin, RL
  • McFarland, JM
  • Miller, RM
  • Frödin, M
  • et al.

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Targeting noncatalytic cysteine residues with irreversible acrylamide-based inhibitors is a powerful approach for enhancing pharmacological potency and selectivity. Nevertheless, concerns about off-target modification motivate the development of reversible

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