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Common brain disorders are associated with heritable patterns of apparent aging of the brain.

  • Author(s): Kaufmann, Tobias
  • van der Meer, Dennis
  • Doan, Nhat Trung
  • Schwarz, Emanuel
  • Lund, Martina J
  • Agartz, Ingrid
  • Alnæs, Dag
  • Barch, Deanna M
  • Baur-Streubel, Ramona
  • Bertolino, Alessandro
  • Bettella, Francesco
  • Beyer, Mona K
  • Bøen, Erlend
  • Borgwardt, Stefan
  • Brandt, Christine L
  • Buitelaar, Jan
  • Celius, Elisabeth G
  • Cervenka, Simon
  • Conzelmann, Annette
  • Córdova-Palomera, Aldo
  • Dale, Anders M
  • de Quervain, Dominique JF
  • Di Carlo, Pasquale
  • Djurovic, Srdjan
  • Dørum, Erlend S
  • Eisenacher, Sarah
  • Elvsåshagen, Torbjørn
  • Espeseth, Thomas
  • Fatouros-Bergman, Helena
  • Flyckt, Lena
  • Franke, Barbara
  • Frei, Oleksandr
  • Haatveit, Beathe
  • Håberg, Asta K
  • Harbo, Hanne F
  • Hartman, Catharina A
  • Heslenfeld, Dirk
  • Hoekstra, Pieter J
  • Høgestøl, Einar A
  • Jernigan, Terry L
  • Jonassen, Rune
  • Jönsson, Erik G
  • Karolinska Schizophrenia Project (KaSP)
  • Kirsch, Peter
  • Kłoszewska, Iwona
  • Kolskår, Knut K
  • Landrø, Nils Inge
  • Le Hellard, Stephanie
  • Lesch, Klaus-Peter
  • Lovestone, Simon
  • Lundervold, Arvid
  • Lundervold, Astri J
  • Maglanoc, Luigi A
  • Malt, Ulrik F
  • Mecocci, Patrizia
  • Melle, Ingrid
  • Meyer-Lindenberg, Andreas
  • Moberget, Torgeir
  • Norbom, Linn B
  • Nordvik, Jan Egil
  • Nyberg, Lars
  • Oosterlaan, Jaap
  • Papalino, Marco
  • Papassotiropoulos, Andreas
  • Pauli, Paul
  • Pergola, Giulio
  • Persson, Karin
  • Richard, Geneviève
  • Rokicki, Jaroslav
  • Sanders, Anne-Marthe
  • Selbæk, Geir
  • Shadrin, Alexey A
  • Smeland, Olav B
  • Soininen, Hilkka
  • Sowa, Piotr
  • Steen, Vidar M
  • Tsolaki, Magda
  • Ulrichsen, Kristine M
  • Vellas, Bruno
  • Wang, Lei
  • Westman, Eric
  • Ziegler, Georg C
  • Zink, Mathias
  • Andreassen, Ole A
  • Westlye, Lars T
  • et al.
Abstract

Common risk factors for psychiatric and other brain disorders are likely to converge on biological pathways influencing the development and maintenance of brain structure and function across life. Using structural MRI data from 45,615 individuals aged 3-96 years, we demonstrate distinct patterns of apparent brain aging in several brain disorders and reveal genetic pleiotropy between apparent brain aging in healthy individuals and common brain disorders.

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