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Engineering macrophages for cancer immunotherapy: emerging insights and therapeutic potential
Published Web Location
https://doi.org/10.1038/s44385-026-00072-yAbstract
Macrophages strongly influence cancer progression through their adaptable phenotypes and responses to mechanical and biochemical cues. Their abundance across tumors and links to poor outcomes drive interest in macrophage-targeted therapies. This review highlights macrophage mechanobiology, key behaviors, and the potential of engineered macrophages, using genetic (CAR) or non-genetic “Trojan horse” and “backpacking” strategies, to deliver therapies and reshape the immunosuppressive tumor microenvironment.
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