Formal Aniline Synthesis from Phenols through Deoxygenative N-Centered Radical Substitution.
- Author(s): Lardy, Samuel W;
- Luong, Kristine C;
- Schmidt, Valerie A
- et al.
Published Web Locationhttps://doi.org/10.1002/chem.201904288
Phenolic, lignin-derived substrates have emerged as desirable biorenewable chemical feedstocks for coupling reactions. A radical-mediated conversion of phenol derivatives to anilines is reported, using unfunctionalized hydroxamic acids as the N-centered radical source. The applicability of this triethyl phosphite mediated O-atom transfer approach, which tolerates a range of steric and electronic demands to naturally occurring phenols and lignin models, has been demonstrated in this work to access the corresponding aniline derivatives.