Skip to main content
eScholarship
Open Access Publications from the University of California

UC Irvine

UC Irvine Previously Published Works bannerUC Irvine

Modeling the regional spread and control of vancomycin-resistant enterococci.

  • Author(s): Lee, Bruce Y;
  • Yilmaz, S Levent;
  • Wong, Kim F;
  • Bartsch, Sarah M;
  • Eubank, Stephen;
  • Song, Yeohan;
  • Avery, Taliser R;
  • Christie, Richard;
  • Brown, Shawn T;
  • Epstein, Joshua M;
  • Parker, Jon I;
  • Huang, Susan S
  • et al.
Abstract

Background

Because patients can remain colonized with vancomycin-resistant enterococci (VRE) for long periods of time, VRE may spread from one health care facility to another.

Methods

Using the Regional Healthcare Ecosystem Analyst, an agent-based model of patient flow among all Orange County, California, hospitals and communities, we quantified the degree and speed at which changes in VRE colonization prevalence in a hospital may affect prevalence in other Orange County hospitals.

Results

A sustained 10% increase in VRE colonization prevalence in any 1 hospital caused a 2.8% (none to 62%) average relative increase in VRE prevalence in all other hospitals. Effects took from 1.5 to >10 years to fully manifest. Larger hospitals tended to have greater affect on other hospitals.

Conclusions

When monitoring and controlling VRE, decision makers may want to account for regional effects. Knowing a hospital's connections with other health care facilities via patient sharing can help determine which hospitals to include in a surveillance or control program.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View