Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.
- Author(s): Feasey, Nicholas A
- Hadfield, James
- Keddy, Karen H
- Dallman, Timothy J
- Jacobs, Jan
- Deng, Xiangyu
- Wigley, Paul
- Barquist, Lars
- Langridge, Gemma C
- Feltwell, Theresa
- Harris, Simon R
- Mather, Alison E
- Fookes, Maria
- Aslett, Martin
- Msefula, Chisomo
- Kariuki, Samuel
- Maclennan, Calman A
- Onsare, Robert S
- Weill, François-Xavier
- Le Hello, Simon
- Smith, Anthony M
- McClelland, Michael
- Desai, Prerak
- Parry, Christopher M
- Cheesbrough, John
- French, Neil
- Campos, Josefina
- Chabalgoity, Jose A
- Betancor, Laura
- Hopkins, Katie L
- Nair, Satheesh
- Humphrey, Tom J
- Lunguya, Octavie
- Cogan, Tristan A
- Tapia, Milagritos D
- Sow, Samba O
- Tennant, Sharon M
- Bornstein, Kristin
- Levine, Myron M
- Lacharme-Lora, Lizeth
- Everett, Dean B
- Kingsley, Robert A
- Parkhill, Julian
- Heyderman, Robert S
- Dougan, Gordon
- Gordon, Melita A
- Thomson, Nicholas R
- et al.
Published Web Location
https://doi.org/10.1038/ng.3644Abstract
An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.
Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.