Skip to main content
eScholarship
Open Access Publications from the University of California
Refine Search

UC Irvine

UC Irvine Previously Published Works bannerUC Irvine

Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

  • Author(s): Feasey, Nicholas A;
  • Hadfield, James;
  • Keddy, Karen H;
  • Dallman, Timothy J;
  • Jacobs, Jan;
  • Deng, Xiangyu;
  • Wigley, Paul;
  • Barquist, Lars;
  • Langridge, Gemma C;
  • Feltwell, Theresa;
  • Harris, Simon R;
  • Mather, Alison E;
  • Fookes, Maria;
  • Aslett, Martin;
  • Msefula, Chisomo;
  • Kariuki, Samuel;
  • Maclennan, Calman A;
  • Onsare, Robert S;
  • Weill, François-Xavier;
  • Le Hello, Simon;
  • Smith, Anthony M;
  • McClelland, Michael;
  • Desai, Prerak;
  • Parry, Christopher M;
  • Cheesbrough, John;
  • French, Neil;
  • Campos, Josefina;
  • Chabalgoity, Jose A;
  • Betancor, Laura;
  • Hopkins, Katie L;
  • Nair, Satheesh;
  • Humphrey, Tom J;
  • Lunguya, Octavie;
  • Cogan, Tristan A;
  • Tapia, Milagritos D;
  • Sow, Samba O;
  • Tennant, Sharon M;
  • Bornstein, Kristin;
  • Levine, Myron M;
  • Lacharme-Lora, Lizeth;
  • Everett, Dean B;
  • Kingsley, Robert A;
  • Parkhill, Julian;
  • Heyderman, Robert S;
  • Dougan, Gordon;
  • Gordon, Melita A;
  • Thomson, Nicholas R
  • et al.

Published Web Location

https://doi.org/10.1038/ng.3644
Abstract

An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.

Main Content
For improved accessibility of PDF content, download the file to your device.
Current View


Top