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Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

  • Author(s): Feasey, Nicholas A;
  • Hadfield, James;
  • Keddy, Karen H;
  • Dallman, Timothy J;
  • Jacobs, Jan;
  • Deng, Xiangyu;
  • Wigley, Paul;
  • Barquist, Lars;
  • Langridge, Gemma C;
  • Feltwell, Theresa;
  • Harris, Simon R;
  • Mather, Alison E;
  • Fookes, Maria;
  • Aslett, Martin;
  • Msefula, Chisomo;
  • Kariuki, Samuel;
  • Maclennan, Calman A;
  • Onsare, Robert S;
  • Weill, François-Xavier;
  • Le Hello, Simon;
  • Smith, Anthony M;
  • McClelland, Michael;
  • Desai, Prerak;
  • Parry, Christopher M;
  • Cheesbrough, John;
  • French, Neil;
  • Campos, Josefina;
  • Chabalgoity, Jose A;
  • Betancor, Laura;
  • Hopkins, Katie L;
  • Nair, Satheesh;
  • Humphrey, Tom J;
  • Lunguya, Octavie;
  • Cogan, Tristan A;
  • Tapia, Milagritos D;
  • Sow, Samba O;
  • Tennant, Sharon M;
  • Bornstein, Kristin;
  • Levine, Myron M;
  • Lacharme-Lora, Lizeth;
  • Everett, Dean B;
  • Kingsley, Robert A;
  • Parkhill, Julian;
  • Heyderman, Robert S;
  • Dougan, Gordon;
  • Gordon, Melita A;
  • Thomson, Nicholas R
  • et al.

Published Web Location

https://doi.org/10.1038/ng.3644
Abstract

An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

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