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Distinct Salmonella Enteritidis lineages associated with enterocolitis in high-income settings and invasive disease in low-income settings.

  • Author(s): Feasey, Nicholas A
  • Hadfield, James
  • Keddy, Karen H
  • Dallman, Timothy J
  • Jacobs, Jan
  • Deng, Xiangyu
  • Wigley, Paul
  • Barquist, Lars
  • Langridge, Gemma C
  • Feltwell, Theresa
  • Harris, Simon R
  • Mather, Alison E
  • Fookes, Maria
  • Aslett, Martin
  • Msefula, Chisomo
  • Kariuki, Samuel
  • Maclennan, Calman A
  • Onsare, Robert S
  • Weill, François-Xavier
  • Le Hello, Simon
  • Smith, Anthony M
  • McClelland, Michael
  • Desai, Prerak
  • Parry, Christopher M
  • Cheesbrough, John
  • French, Neil
  • Campos, Josefina
  • Chabalgoity, Jose A
  • Betancor, Laura
  • Hopkins, Katie L
  • Nair, Satheesh
  • Humphrey, Tom J
  • Lunguya, Octavie
  • Cogan, Tristan A
  • Tapia, Milagritos D
  • Sow, Samba O
  • Tennant, Sharon M
  • Bornstein, Kristin
  • Levine, Myron M
  • Lacharme-Lora, Lizeth
  • Everett, Dean B
  • Kingsley, Robert A
  • Parkhill, Julian
  • Heyderman, Robert S
  • Dougan, Gordon
  • Gordon, Melita A
  • Thomson, Nicholas R
  • et al.

Published Web Location

https://doi.org/10.1038/ng.3644
Abstract

An epidemiological paradox surrounds Salmonella enterica serovar Enteritidis. In high-income settings, it has been responsible for an epidemic of poultry-associated, self-limiting enterocolitis, whereas in sub-Saharan Africa it is a major cause of invasive nontyphoidal Salmonella disease, associated with high case fatality. By whole-genome sequence analysis of 675 isolates of S. Enteritidis from 45 countries, we show the existence of a global epidemic clade and two new clades of S. Enteritidis that are geographically restricted to distinct regions of Africa. The African isolates display genomic degradation, a novel prophage repertoire, and an expanded multidrug resistance plasmid. S. Enteritidis is a further example of a Salmonella serotype that displays niche plasticity, with distinct clades that enable it to become a prominent cause of gastroenteritis in association with the industrial production of eggs and of multidrug-resistant, bloodstream-invasive infection in Africa.

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