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Symmetric adamantyl-diureas as soluble epoxide hydrolase inhibitors
- Burmistrov, Vladimir;
- Morisseau, Christophe;
- Lee, Kin Sing Stephen;
- Shihadih, Diyala S;
- Harris, Todd R;
- Butov, Gennady M;
- Hammock, Bruce D
Published Web Location
https://doi.org/10.1016/j.bmcl.2014.03.016Abstract
A series of inhibitors of the soluble epoxide hydrolase (sEH) containing two urea groups has been developed. Inhibition potency of the described compounds ranges from 2.0 μM to 0.4 nM. 1,6-(Hexamethylene)bis[(adamant-1-yl)urea] (3b) was found to be a potent slow tight binding inhibitor (IC50=0.5 nM) with a strong binding to sEH (Ki=3.1 nM) and a moderately long residence time on the enzyme (koff=1.05 × 10(-3) s(-1); t1/2=11 min).
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