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Cellular immune activity biomarker neopterin is associated hyperlipidemia: results from a large population-based study
- Chuang, Shu-Chun;
- Boeing, Heiner;
- Vollset, Stein Emil;
- Midttun, Øivind;
- Ueland, Per Magne;
- Bueno-de-Mesquita, Bas;
- Lajous, Martin;
- Fagherazzi, Guy;
- Boutron-Ruault, Marie-Christine;
- Kaaks, Rudolf;
- Küehn, Tilman;
- Pischon, Tobias;
- Drogan, Dagmar;
- Tjønneland, Anne;
- Overvad, Kim;
- Quirós, J Ramón;
- Agudo, Antonio;
- Molina-Montes, Esther;
- Dorronsoro, Miren;
- Huerta, José María;
- Barricarte, Aurelio;
- Khaw, Kay-Tee;
- Wareham, Nicholas J;
- Travis, Ruth C;
- Trichopoulou, Antonia;
- Lagiou, Pagona;
- Trichopoulos, Dimitrios;
- Masala, Giovanna;
- Agnoli, Claudia;
- Tumino, Rosario;
- Mattiello, Amalia;
- Peeters, Petra H;
- Weiderpass, Elisabete;
- Palmqvist, Richard;
- Ljuslinder, Ingrid;
- Gunter, Marc;
- Lu, Yunxia;
- Cross, Amanda J;
- Riboli, Elio;
- Vineis, Paolo;
- Aleksandrova, Krasimira
- et al.
Published Web Location
https://doi.org/10.1186/s12979-016-0059-yAbstract
Background
Increased serum neopterin had been described in older age two decades ago. Neopterin is a biomarker of systemic adaptive immune activation that could be potentially implicated in metabolic syndrome (MetS). Measurements of waist circumference, triglycerides, high-density lipoprotein cholesterol (HDLC), systolic and diastolic blood pressure, glycated hemoglobin as components of MetS definition, and plasma total neopterin concentrations were performed in 594 participants recruited in the European Prospective Investigation into Cancer and Nutrition (EPIC).Results
Higher total neopterin concentrations were associated with reduced HDLC (9.7 %, p < 0.01 for men and 9.2 %, p < 0.01 for women), whereas no association was observed with the rest of the MetS components as well as with MetS overall (per 10 nmol/L: OR = 1.42, 95 % CI = 0.85-2.39 for men and OR = 1.38, 95 % CI = 0.79-2.43).Conclusions
These data suggest that high total neopterin concentrations are cross-sectionally associated with reduced HDLC, but not with overall MetS.Many UC-authored scholarly publications are freely available on this site because of the UC's open access policies. Let us know how this access is important for you.
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