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Targeting of αv integrin identifies a core molecular pathway that regulates fibrosis in several organs

  • Author(s): Maher, Jacquelyn
  • Sheppard, Dean
  • Henderson, NC
  • Arnold, TD
  • Katamura, Y
  • Giacomini, MM
  • Rodriguez, JD
  • McCarty, JH
  • Pellicoro, A
  • Raschperger, E
  • Betsholtz, C
  • Ruminski, PG
  • et al.

Published Web Location

http://europepmc.org/articles/PMC3855865?pdf=render
No data is associated with this publication.
Abstract

Myofibroblasts are the major source of extracellular matrix components that accumulate during tissue fibrosis, and hepatic stellate cells (HSCs) are believed to be the major source of myofibroblasts in the liver. To date, robust systems to genetically mani

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