Resurrected Ancestors Reveal Origins of Metamorphism in XCL1.
Published Web Locationhttps://doi.org/10.1016/j.tibs.2021.03.003
In a recent study, Dishman et al. resurrected ancestors of the metamorphic chemokine, XCL1, inferred through phylogenetics, and found that metamorphism arose in the XCL1 lineage ~150 million years ago. A zigzagging evolutionary path suggests that the metamorphic properties are adaptive and reveals three design principles that could be used for technological applications.