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A renewed model of pancreatic cancer evolution based on genomic rearrangement patterns
- Notta, Faiyaz;
- Chan-Seng-Yue, Michelle;
- Lemire, Mathieu;
- Li, Yilong;
- Wilson, Gavin W;
- Connor, Ashton A;
- Denroche, Robert E;
- Liang, Sheng-Ben;
- Brown, Andrew MK;
- Kim, Jaeseung C;
- Wang, Tao;
- Simpson, Jared T;
- Beck, Timothy;
- Borgida, Ayelet;
- Buchner, Nicholas;
- Chadwick, Dianne;
- Hafezi-Bakhtiari, Sara;
- Dick, John E;
- Heisler, Lawrence;
- Hollingsworth, Michael A;
- Ibrahimov, Emin;
- Jang, Gun Ho;
- Johns, Jeremy;
- Jorgensen, Lars GT;
- Law, Calvin;
- Ludkovski, Olga;
- Lungu, Ilinca;
- Ng, Karen;
- Pasternack, Danielle;
- Petersen, Gloria M;
- Shlush, Liran I;
- Timms, Lee;
- Tsao, Ming-Sound;
- Wilson, Julie M;
- Yung, Christina K;
- Zogopoulos, George;
- Bartlett, John MS;
- Alexandrov, Ludmil B;
- Real, Francisco X;
- Cleary, Sean P;
- Roehrl, Michael H;
- McPherson, John D;
- Stein, Lincoln D;
- Hudson, Thomas J;
- Campbell, Peter J;
- Gallinger, Steven
Published Web Location
https://doi.org/10.1038/nature19823Abstract
Pancreatic cancer is not caused by a specific series of genetic alterations that occur sequentially but by one, or few, catastrophic events that result in simultaneous oncogenic genetic rearrangements, giving rise to highly aggressive tumours.
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