Skip to main content
Open Access Publications from the University of California

Calcium Coordination Solids for pH-Triggered Release of Olsalazine

  • Author(s): Levine, DJ
  • Gonzalez, MI
  • Legendre, CM
  • Runčevski, T
  • Oktawiec, J
  • Colwell, KA
  • Long, JR
  • et al.

© 2017 Wiley-VCH Verlag GmbH & Co. KGaA, Weinheim Calcium coordination solids were synthesized and evaluated for delivery of olsalazine (H4olz), an anti-inflammatory compound used for treatment of ulcerative colitis. The materials include one-dimensional Ca(H2olz)⋅4 H2O chains, two-dimensional Ca(H2olz)⋅2 H2O sheets, and a three-dimensional metal-organic framework Ca(H2olz)⋅2DMF (DMF=N,N-dimethylformamide). The framework undergoes structural changes in response to solvent, forming a dense Ca(H2olz) phase when exposed to aqueous HCl. The compounds Ca(H2olz)⋅x H2O (x=0, 2, 4) were each pressed into pellets and exposed to simulated gastrointestinal fluids to mimic the passage of a pill from the acidic stomach to the pH-neutral intestines. All three calcium materials exhibited a delayed release of olsalazine relative to Na2(H2olz), the commercial formulation, illustrating how formulation of a drug within an extended coordination solid can serve to tune its solubility and performance.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Main Content
Current View