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Application of Orthogonal Array Composite Designs to Study Lipid Accumulation


Nowadays, the world is to develop renewable energy and algal biofuel is a promis-

ing alternative to fossil fuel. However the high cost of commercial culture median,

like Modied Bold 3N is an insuperable bottleneck in the large-scale production

of algae-based biofuels. In this paper, we use orthogonal array composite designs

(OACDs) to search optimal chemical combination settings. We initially use a 52-

run OACD with six dierent chemicals. Data analysis suggests that two chemicals

could be excluded from combination since they lack of signicance. To further

study, a follow-up 28-run OACD using four chemicals indicates the optimal com-

bination settings for these chemicals.

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