Successes and challenges in phenotype-based lead discovery for prion diseases
- Author(s): Renslo, Adam;
- Ghaemmaghami, S;
- Russo, M;
- Renslo, AR
- et al.
Published Web Locationhttp://europepmc.org/articles/PMC4148153?pdf=render
Creutzfeldt-Jakob disease (CJD) is a rare but invariably fatal neurodegenerative disease caused by misfolding of an endogenous protein into an alternative pathogenic conformation. The details of protein misfolding and aggregation are not well understood no