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Successes and challenges in phenotype-based lead discovery for prion diseases

  • Author(s): Renslo, Adam
  • Ghaemmaghami, S
  • Russo, M
  • Renslo, AR
  • et al.

Published Web Location

http://europepmc.org/articles/PMC4148153?pdf=render
No data is associated with this publication.
Abstract

Creutzfeldt-Jakob disease (CJD) is a rare but invariably fatal neurodegenerative disease caused by misfolding of an endogenous protein into an alternative pathogenic conformation. The details of protein misfolding and aggregation are not well understood no

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