Skip to main content
eScholarship
Open Access Publications from the University of California

Increased HIV-1 transcriptional activity and infectious burden in peripheral blood and gut-associated CD4+T cells expressing CD30

  • Author(s): Hogan, LE
  • Vasquez, J
  • Hobbs, KS
  • Hanhauser, E
  • Aguilar-Rodriguez, B
  • Hussien, R
  • Thanh, C
  • Gibson, EA
  • Carvidi, AB
  • Smith, LCB
  • Khan, S
  • Trapecar, M
  • Sanjabi, S
  • Somsouk, M
  • Stoddart, CA
  • Kuritzkes, DR
  • Deeks, SG
  • Henrich, TJ
  • et al.

Published Web Location

http://journals.plos.org/plospathogens/article?id=10.1371/journal.ppat.1006856
No data is associated with this publication.
Creative Commons Attribution-ShareAlike 4.0 International Public License
Abstract

© 2018 Hogan et al. HIV-1-infected cells persist indefinitely despite the use of combination antiretroviral therapy (ART), and novel therapeutic strategies to target and purge residual infected cells in individuals on ART are urgently needed. Here, we demonstrate that CD4+T cell-associated HIV-1 RNA is often highly enriched in cells expressing CD30, and that cells expressing this marker considerably contribute to the total pool of transcriptionally active CD4+lymphocytes in individuals on suppressive ART. Using in situ RNA hybridization studies, we show co-localization of CD30 with HIV-1 transcriptional activity in gut-associated lymphoid tissues. We also demonstrate that ex vivo treatment with brentuximab vedotin, an antibody-drug conjugate (ADC) that targets CD30, significantly reduces the total amount of HIV-1 DNA in peripheral blood mononuclear cells obtained from infected, ART-suppressed individuals. Finally, we observed that an HIV-1-infected individual, who received repeated brentuximab vedotin infusions for lymphoma, had no detectable virus in peripheral blood mononuclear cells. Overall, CD30 may be a marker of residual, transcriptionally active HIV-1 infected cells in the setting of suppressive ART. Given that CD30 is only expressed on a small number of total mononuclear cells, it is a potential therapeutic target of persistent HIV-1 infection.

Many UC-authored scholarly publications are freely available on this site because of the UC Academic Senate's Open Access Policy. Let us know how this access is important for you.

Item not freely available? Link broken?
Report a problem accessing this item