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Defusing inflammasomes.

  • Author(s): Sandstrom, Andrew
  • VANCE, Russell E.
  • et al.
Abstract

In this issue of JEM, Boucher et al. (https://doi.org/10.1084/jem.20172222) report isolation of active caspase-1 from macrophages after inflammasome activation. Surprisingly, they find that caspase-1 is quickly inactivated upon autoproteolytic processing.

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