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A genome-wide association meta-analysis identifies new childhood obesity loci
- Bradfield, Jonathan P;
- Taal, H Rob;
- Timpson, Nicholas J;
- Scherag, André;
- Lecoeur, Cecile;
- Warrington, Nicole M;
- Hypponen, Elina;
- Holst, Claus;
- Valcarcel, Beatriz;
- Thiering, Elisabeth;
- Salem, Rany M;
- Schumacher, Fredrick R;
- Cousminer, Diana L;
- Sleiman, Patrick MA;
- Zhao, Jianhua;
- Berkowitz, Robert I;
- Vimaleswaran, Karani S;
- Jarick, Ivonne;
- Pennell, Craig E;
- Evans, David M;
- St Pourcain, Beate;
- Berry, Diane J;
- Mook-Kanamori, Dennis O;
- Hofman, Albert;
- Rivadeneira, Fernando;
- Uitterlinden, André G;
- van Duijn, Cornelia M;
- van der Valk, Ralf JP;
- de Jongste, Johan C;
- Postma, Dirkje S;
- Boomsma, Dorret I;
- Gauderman, W James;
- Hassanein, Mohamed T;
- Lindgren, Cecilia M;
- Mägi, Reedik;
- Boreham, Colin AG;
- Neville, Charlotte E;
- Moreno, Luis A;
- Elliott, Paul;
- Pouta, Anneli;
- Hartikainen, Anna-Liisa;
- Li, Mingyao;
- Raitakari, Olli;
- Lehtimäki, Terho;
- Eriksson, Johan G;
- Palotie, Aarno;
- Dallongeville, Jean;
- Das, Shikta;
- Deloukas, Panos;
- McMahon, George;
- Ring, Susan M;
- Kemp, John P;
- Buxton, Jessica L;
- Blakemore, Alexandra IF;
- Bustamante, Mariona;
- Guxens, Mònica;
- Hirschhorn, Joel N;
- Gillman, Matthew W;
- Kreiner-Møller, Eskil;
- Bisgaard, Hans;
- Gilliland, Frank D;
- Heinrich, Joachim;
- Wheeler, Eleanor;
- Barroso, Inês;
- O'Rahilly, Stephen;
- Meirhaeghe, Aline;
- Sørensen, Thorkild IA;
- Power, Chris;
- Palmer, Lyle J;
- Hinney, Anke;
- Widen, Elisabeth;
- Farooqi, I Sadaf;
- McCarthy, Mark I;
- Froguel, Philippe;
- Meyre, David;
- Hebebrand, Johannes;
- Jarvelin, Marjo-Riitta;
- Jaddoe, Vincent WV;
- Smith, George Davey;
- Hakonarson, Hakon;
- Grant, Struan FA
Published Web Location
https://doi.org/10.1038/ng.2247Abstract
Struan Grant and colleagues perform a meta-analysis of genome-wide association studies to identify loci influencing childhood obesity. They discover variants near OLFM4 and HOXB5 associated with this trait and show that these loci are also associated with increased body mass index in adults.
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