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Dependency of a therapy-resistant state of cancer cells on a lipid peroxidase pathway
- Viswanathan, Vasanthi S;
- Ryan, Matthew J;
- Dhruv, Harshil D;
- Gill, Shubhroz;
- Eichhoff, Ossia M;
- Seashore-Ludlow, Brinton;
- Kaffenberger, Samuel D;
- Eaton, John K;
- Shimada, Kenichi;
- Aguirre, Andrew J;
- Viswanathan, Srinivas R;
- Chattopadhyay, Shrikanta;
- Tamayo, Pablo;
- Yang, Wan Seok;
- Rees, Matthew G;
- Chen, Sixun;
- Boskovic, Zarko V;
- Javaid, Sarah;
- Huang, Cherrie;
- Wu, Xiaoyun;
- Tseng, Yuen-Yi;
- Roider, Elisabeth M;
- Gao, Dong;
- Cleary, James M;
- Wolpin, Brian M;
- Mesirov, Jill P;
- Haber, Daniel A;
- Engelman, Jeffrey A;
- Boehm, Jesse S;
- Kotz, Joanne D;
- Hon, Cindy S;
- Chen, Yu;
- Hahn, William C;
- Levesque, Mitchell P;
- Doench, John G;
- Berens, Michael E;
- Shamji, Alykhan F;
- Clemons, Paul A;
- Stockwell, Brent R;
- Schreiber, Stuart L
Published Web Location
https://doi.org/10.1038/nature23007Abstract
Therapy-resistant cancer cell states identified across diverse contexts are selectively vulnerable to ferroptotic cell death induced by inhibition of lipid peroxidase pathways converging on GPX4.
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