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Chemotropic guidance facilitates axonal regeneration and synapse formation after spinal cord injury
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https://doi.org/10.1038/nn.2365Abstract
The authors report a successfully targeted reinnervation of hindlimb sensory fibers projection into the CNS following spinal cord injury in rats. Cervical level 1 lesions followed by expression of the neurotrophin NT-3 in the appropriate brainstem target led to proper targeting of regenerating axons.
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